Novel antiviral properties of azithromycin in cystic fibrosis airway epithelial cells.

Restoration of chloride efflux by azithromycin in airway epithelial cells of cystic fibrosis patients.

Azithromycin (AZM) has shown promising anti-inflammatory properties in chronic obstructive pulmonary diseases, and clinical studies have presented an improvement in the respiratory condition of cystic fibrosis (CF) patients. The aim of this study was to investigate, in human airway cells, the mechanism by which AZM has beneficial effects in CF. We demonstrated that AZM did not have any anti-inf...

Maintaining Respiratory Health in Cystic Fibrosis Patients

Cystic fibrosis (CF) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. More than 90% of mortality of  CF patients is due to lung complications.  Healthy lungs are important for a long life for people with CF, We will discuss two important topics for maintaining respiratory health. Chronic use of drug...

Fibrosis Airway Epithelial Cells Necrosis Factor Alpha Levels in Cystic Azithromycin Selectively Reduces Tumor

Azithromycin Selectively Reduces Tumor Necrosis Factor

1 CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS. 2 3 Running title: Azithromycin reduces TNF-α in cystic fibrosis cells. 4 Cristina Cigana, Baroukh Maurice Assael and Paola Melotti* 5 Cystic Fibrosis Center, Azienda Ospedaliera di Verona, Verona, ITALY. 6 7 *Corresponding author. Mailing address: Cystic Fibrosis Center Azienda Ospedaliera di 8 Verona, piazzale Stefani, 1 37126 Verona, Italy. Phone: +...

Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients.

There is considerable interest in the use of azithromycin for the treatment of lung disease in patients with cystic fibrosis (CF). Although its mechanism of action as an inhibitor of bacterial protein synthesis has been well-established, it is less clear how azithromycin ameliorates the lung disease associated with Pseudomonas aeruginosa, which is considered to be resistant to the drug. We test...